Endocrine Abstracts

Endocrinology came to its third revolution in the field of hormone determination. As radioimmunoassays in the 60s paved the way to the knowledge of modern endocrinology, and as automated immunoassays in the 70s linked analytical measurement to the clinical practice, nowadays liquid chromatography – tandem mass spectrometry (LC–MS/MS) represents the evolution of the high-throughput approach, typical of automated platforms, toward the high reliability and specificity o...

During the last few years, the endocannabinoid system has emerged as a relevant topic in the scientific community. Many different regulatory actions have been attributed to endocannabinoids, and their involvement in several pathophysiological conditions is under intense scrutiny. Cannabinoid receptors first discovered as the molecular targets of the psychotropic component of the plant Cannabis sativa, participate in the physiological modulation of many central and peripheral f...

First described in 1956, Prader-Labhart-Willi syndome is a rare, complex neurodevelopmental disorder characterised by short stature, disturbed body composition with hyperphagia and hypoactivity, hypogonadism, cryptorchidism, oligophrenia, behaviour problems as well as extreme muscular hypotonia in the neonatal period. Its estimated prevalence ranges from 1:15,000–25,000 and it is caused by an absence of expression of paternally active genes in the PWS critical region on c...

Case history: We report a 25-year-old man who presented to Neurology with two years history of a migrainous headache mainly at night. MRI head scan demonstrated large lobulated pituitary macroadenoma with significant suprasellar extension and anterior visual pathway compromise along with distortion of the basal forebrain, particularly on the right. Consequently, he was referred to the endocrinology team for further management. Upon initial assessment, he reported foot size enl...

Introduction: Reproductive health is closely related with nutritional status of a country. Nutritional problems are different between developed and developing countries. In the context of Bangladesh there is no recent assessment. This study aims to assess the nutritional status and reproductive morbidity among women in Dhaka city.Description of methods: A cross-sectional study was performed in 400 women, aged 15–40 years, in Dhaka city. Sample was s...

Aim: The work was initiated to compared extent of physical and sexual development retardation in adolescents with various neuroendocrine abnormalities.Materials and methods: We examined 63 adolescents, 41 boys (59.4%) and 22 girls (34.9%) among them with various endocrine abnormalities. Mean age of boys and girls was 11.3 and 12 years, respectively. All patients underwent general clinical examination. Levels of STH, LH, FSH, prolactin, TSH, ACTH, cortiso...

A 35-year-old lady presented 20 years ago with difficulty in walking. She was born in Newcastle and was brought up by her mother with no contact with father. Early childhood was further traumatised when mother moved in with a man affected from multiple sclerosis with whom she never adjusted. Consequently, she was placed with two foster parents but could not adjust there either. Two years earlier, she was admitted in hospital with drug overdose. By age 25, she had hypothyroidis...

Even though it is unusual, many cases presenting with combinations of thyroid carcinomas have been reported. Concurrent occurances of medullary – papllary carcinoma, follicular – papillary – medullary carcinoma, follicular – anaplastik – papillary carcinoma, papillary – follicular carcinoma have been presented. The cases reported up to now had no thyroid autoimmunity. We present a case with known Hashimoto’s thyroiditis having a combination o...